Paternal exposure to chemicals before conception.

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Paternal occupational exposure around conception and spina bifida in offspring.

A multi-center case-referent study was conducted on the relation between paternal occupational exposure and spina bifida in offspring. Cases were born between 1980 and 1992 in The Netherlands. Referents were recruited from hospitals and from the general population. Postal questionnaires were used to gather information on occupation and potential confounders. Through job-specific telephone inter...

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Paternal use of ribavirin-interferon alpha 2B combination therapy before conception.

QUESTION One of my male patients is receiving ribavirin-interferon alpha 2B (Pegetron) combination therapy for chronic hepatitis C. His wife recently found out she is 6 weeks pregnant. They are concerned that the medications might have affected his sperm. How should I advise them? ANSWER To the best of our knowledge, paternal exposure to ribavirin-interferon alpha 2B has no adverse effects on...

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Exposure to chemical cocktails before or after conception – The effect of timing on ovarian development☆

Exposure of female fetuses to environmental chemicals (ECs) during pregnancy results in a disturbed ovarian adult phenotype. We investigated the influence of pre- and/or post-conception exposure to low-level mixtures of ECs on the structure and function of the fetal ovine ovary. We examined ovarian morphology, expression of oocyte and granulosa cell-specific genes and proteome. Female fetuses w...

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Paternal exposure to mercury and spontaneous abortions.

The potential reproductive toxicity of mercury vapour was investigated by comparing the rate of spontaneous abortions among the wives of 152 workers occupationally exposed to mercury vapour with the rate among the wives of 374 controls in the same plant. The results indicate an increase in the rate of spontaneous abortions with an increasing concentration of mercury in the fathers' urine before...

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Paternal Occupational Exposure to Solvents and The Risk of Congenital Heart Defects in Children Using Job Exposure Matrix

Background and aims: Currently, as a result of research on laboratory animals, abundant information has been obtained on the impact of various environmental factors on the occurrence of congenital malformations, but there is still no comprehensive information on the causes of congenital heart malformations (CHD) in human populations. Congenital heart defects (CHDs) constitute the major class of...

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ژورنال

عنوان ژورنال: BMJ

سال: 1993

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.307.6913.1214